Research Article
Phytochemical Profile and Biological Activities of Piliostigma Thonningii Leaf Extract: Antioxidant and Anti-Inflammatory Properties
Issue:
Volume 12, Issue 5, October 2024
Pages:
95-104
Received:
10 September 2024
Accepted:
29 September 2024
Published:
31 October 2024
Abstract: The study aimed to evaluate the phytochemical composition, antioxidant activity, and anti-inflammatory properties of the methanol extract of Piliostigma thonningii leaves to provide scientific evidence for its traditional medicinal use. Phytochemical screening was conducted using standard methods, revealing the presence of anthraquinones, alkaloids, cardiac glycosides, tannins, flavonoids, phytosterols, saponins, and steroids, while glycosides and phenols were absent. Antioxidant activities were assessed using DPPH radical-scavenging, ferric reducing antioxidant potential (FRAP), and hydrogen peroxide scavenging assays, all indicating significant antioxidant capacity that increased with extract concentration. The results indicate a dose-dependent antioxidant response across all assays, with higher concentrations of extracts exhibiting greater scavenging potential against free radicals and hydrogen peroxide-induced oxidation. While the extracts show slightly lower potency compared to ascorbic acid, they still demonstrate considerable antioxidant activity, especially at higher concentrations. The anti-inflammatory effect was evaluated using a carrageenan-induced paw edema model in rats, comparing three dosages of the extract (100, 200, and 400 mg/kg) to Diclofenac and a negative control. The 100 mg/kg dose effectively delayed peak inflammation, showing strong anti-inflammatory activity similar to, but less consistent than, Diclofenac. These findings support the traditional use of Piliostigma thonningii leaves in managing inflammation and pain, suggesting potential for further development as a natural therapeutic agent."
Abstract: The study aimed to evaluate the phytochemical composition, antioxidant activity, and anti-inflammatory properties of the methanol extract of Piliostigma thonningii leaves to provide scientific evidence for its traditional medicinal use. Phytochemical screening was conducted using standard methods, revealing the presence of anthraquinones, alkaloids...
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Research Article
Adsorption of Sodiumoleate on Barite in Aqueous Solution: A Kinetics and Thermodynamic Study
Agbaghare Daniel Enajeme*
Issue:
Volume 12, Issue 5, October 2024
Pages:
105-111
Received:
20 September 2024
Accepted:
8 October 2024
Published:
31 October 2024
Abstract: Concern has been raised about the necessity of separating barite from other minerals. When barite needs to be separated from other minerals, sodiumoleate, also known as napoleate, works well as an adsorbate. The purpose of this work is to examine the impact of temperature, pH, and contact duration on different Na-oleate adsorption methods onto barite. The change in the oleate concentration was used to determine the adsorption of sodium oleate on barite. In a batch adsorption experiment, sodium hydroxide and NaOH solution were combined with oleic acid in different flasks to create sodium oleate. To flasks containing Na-oleate, 1g of purified barite was added. A mechanical shaker was used to shake the specimen flasks and their contents for one hour. After stirring, the contents of each flask were given another 30 minutes to settle. Filter paper was used to filter the contents of the flask. Following filtering, the concentration of each filtrate was red-marked from the calibration graph by measuring the surface tension of each filtrate using a traveling microscope. The investigation's findings demonstrate that the first-order reaction kinetics are followed by the initial rate of Na-oleate adsorption onto barite. This study indicates that adsorption of Naoleate onto calcite increases at low pH values than higher pH. The amount of Na-oleate adsorbed onto calcite increases gradually as temperature increases from 303K to 313K. Beyond optimum temperature 322K, adsorption of Na-oleate on barite decreases rapidly. This study indicates optimum contact time of 80 min on adsorption process of Na-oleate onto calcite. Also this study indicates that adsorption of Na-oleate onto barite is pH dependent. Barite-oleate formation first increases with increasing Na-oleate concentration. At low pH 4, adsorption of Na-oleate onto barite increases, whereas adsorption decreases at high pH 9. Result also demonstrates that pseudo 2nd order offered an excellent fitting in the adsorption of oleate on barite, furthermore, the Langmuir adsorption isotherm favors the interaction between oleate ions and barite more than the Freundlich's isotherm, with the Langmiur isotherm's correlation coefficient (0.9728) being greater than the Freundlich's isotherm (0.9626). The trend of decreasing ∆GO negative values as temperature rises suggests that a higher temperature will more effectively promote oleate adsorption on barite.
Abstract: Concern has been raised about the necessity of separating barite from other minerals. When barite needs to be separated from other minerals, sodiumoleate, also known as napoleate, works well as an adsorbate. The purpose of this work is to examine the impact of temperature, pH, and contact duration on different Na-oleate adsorption methods onto bari...
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