Volume 1, Issue 2, June 2013, Page: 22-27
Central Composite Experimental Design Applied to the Catalytic Carbon-Sulfur Bond Formation by Fluorapatite Catalyst
Younes Abrouki, Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Abdelkader Anouzla, Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Hayat Loukili, Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Rabiaâ Lotfi, Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Ahmed Rayadh, Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
My Abdellah Bahlaoui, Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Saı̈d Sebti, Department of Chemistry, Faculty of Science Ben M'Sik, University Hassan II, Casablanca, Morocco
Driss Zakarya, Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Mohamed Zahouily, Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Received: May 28, 2013;       Published: Jun. 30, 2013
DOI: 10.11648/j.ajac.20130102.12      View  3298      Downloads  197
Abstract
The aim of this study was to apply experimental design in the optimization of the thia-Michael addition reaction between chalcone derivatives and mercaptans catalyzed by Fluorapatite catalyst (FAP). The central composite design was used to design an experimental program to provide data to model the effects of various factors on reaction yield (Y). The variables chosen were catalyst weight (X1), reaction time (X2) and solvent volume (X3). The mathematical relationship of reaction yield on the three significant independent variables can be approximated by a nonlinear polynomial model. Predicted values were found to be in good agreement with experimental values. The optimum reaction conditions (x1= 350 mg, x2= 30 min and x3= 2 mL) for reaction model (chalcone and thiophenol) obtained by response surface were applied to other substrates. This study has shown that central composite design could efficiently be applied for the modeling of catalytic carbon-sulfur bond formation by FAP catalyst under mild reaction condition with high yield, and it is an economical way of obtaining the maximum amount of information with the fewest number of experiments.
Keywords
Carbon-Sulfur Bond Formation, Fluorapatite, Heterogenous Catalyst, Central Composite Design, Response Surface Methodology
To cite this article
Younes Abrouki, Abdelkader Anouzla, Hayat Loukili, Rabiaâ Lotfi, Ahmed Rayadh, My Abdellah Bahlaoui, Saı̈d Sebti, Driss Zakarya, Mohamed Zahouily, Central Composite Experimental Design Applied to the Catalytic Carbon-Sulfur Bond Formation by Fluorapatite Catalyst, American Journal of Applied Chemistry. Vol. 1, No. 2, 2013, pp. 22-27. doi: 10.11648/j.ajac.20130102.12
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