Volume 6, Issue 4, August 2018, Page: 147-155
Physical and Spectral Characterization of Ni (II) Cu(II) Co(II) and Cd(II) Complexes with Schiff Base of Salicylaldehyde and 2-Aminopyridine Towards Potential Microbial Application
Md. Motahar Hossain, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
Md. Abul Bashar, Department of Textile Engineering, Khwaja Yunus Ali University, Sirajgonj, Bangladesh
Md. Nuruzzaman Khan, Department of Chemistry, Begum Rokeya University, Rangpur, Bangladesh
Pijush Kanti Roy, Department of Chemistry, Begum Rokeya University, Rangpur, Bangladesh
Md. Abdul Mannan, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
Md. Siddik Ali, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
Md. Akhter Farooque, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
Received: Sep. 1, 2018;       Accepted: Oct. 6, 2018;       Published: Oct. 29, 2018
DOI: 10.11648/j.ajac.20180604.13      View  132      Downloads  15
A Schiff base (SB) is derived from salicylaldehyde and 2-aminopyridine. The transition metal complexes of N i(II), Cu (II), Co and Cd (II) metal ions were prepared with this Schiff base (SB), which were used as ligand. Several physical tools, in particular; elemental analysis, molar conductivity, magnetic susceptibility, infrared spectroscopy (IR), electronic absorption spectroscopy (ESR) to investigate the chemical structure of the prepared transition metal complexes. The elemental analysis data shows the formation of 1:2 [M:2L] complex of the formula of M2+L2, where M2+ =Ni(II), Cu(II), Co(II), Cd(II) and L = Schiff base (SB). The molar conductance (conductivity) measurements were revealed that all the complexes are non-electrolyte in nature. The infrared (IR) spectral studies indicated the binding sites of the Schiff base ligand with the transition metal ions. The magnetic susceptibility measurements and electronic spectral results supported the predicted coordination geometry of the complexes and magnetic properties (para or dia-magnetic nature) of the complexes. The Ni(II), Cu(II), Co(II) ion forms high spin tetrahedral geometry, whereas Cd(II) ion forms low spin tetrahedral structure. The free Schiff base and its complexes have been tested for their antimicrobial activities against four human pathogenic (two gram-positive and two gram-negative) bacteria. The obtained results showed that only Cu(II) complex exhibited strong activity toward human pathogenic gram positive and gram negative bacteria whereas the Ni(II), Co(II) and Cd(II) complexes showed week to moderate antimicrobial activity compared with standard Kanamycin and Ampicillin.
Schiff Base, Metal Complex, Spectral Studies, Antimicrobial Activity
To cite this article
Md. Motahar Hossain, Md. Abul Bashar, Md. Nuruzzaman Khan, Pijush Kanti Roy, Md. Abdul Mannan, Md. Siddik Ali, Md. Akhter Farooque, Physical and Spectral Characterization of Ni (II) Cu(II) Co(II) and Cd(II) Complexes with Schiff Base of Salicylaldehyde and 2-Aminopyridine Towards Potential Microbial Application, American Journal of Applied Chemistry. Vol. 6, No. 4, 2018, pp. 147-155. doi: 10.11648/j.ajac.20180604.13
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Crişan R, Modra D (2013) The synthesis of salicylaldehyde varying different parameters. J. West University of Timişoara, Series of Chemistry 22: 57-66.
Simmonds J, Robinson GK (1998) Formation of Benzaldehyde by Pseudomonas putida ATCC 12633. Appl. Microbial Biotechnol 50:353-358.
Dueke-Eze CU, Fasina TM, Idika N (2011) Synthesis, electronic spectra and inhibitory study of some Salicylaldehyde Schiff bases of 2-aminopyridine. African Journal of Pure and Applied Chemistry 5:13-18.
Schiff W, Szady CA, Grech E, Przybylski P, Brzezinski B (2002) Spectroscopic studies of new Schiff and Schiff–Mannich bases of ortho-derivatives of 4-bromophenol. J. Mol. Struct. 643:115-121.
Prisakar VI, Tsapkov VI, Buracheeva SA, Byrke MS, Gulya AP (2005) Synthesis and antimicrobial activity of coordination compounds of copper with substituted salicylaldehyde thiosemicarbazones. Pharm. Chem. J. 39: 30-32.
Naturforsch Z, Pelttari E, Karhumaki E, Langshaw J, Perakyla H, Elo H (2007) Antimicrobial properties of substituted salicylaldehyde and related compounds. J. Biosci. 62C: 487-497.
Tsapkov VI, Prisacar VI, Buracheva SA, Lazakovich DV, Gulya AP (2008) Synthesis and antimicrobial activity of sulfazine-containing copper(II) coordination compounds with substituted salicylaldehydebenzoylhydrazones. Pharm. Chem. J. 42: 523-526.
Shi L, Ge HM, Tan SH, Li HQ, Song YC, Zhu HL, Tan RX (2007) Synthesis and antimicrobial activity of Schiff bases derived from 5-chloro-salicylaldehyde. Eur. J. Med. Chem.42: 558-564.
Uddin MN, Chowdhury DA, Rony MM, Halim ME (2014) Metal complexes of Schiff bases derived from 2-thiophenecarboxaldehyde and mono/diamine as the antibacterial agents. j. Science publishing group 2: 6-14.
Jamuna K, Naik BR, Sreenu B, Seshaiah K (2012) Synthesis, characterization and antibacterial activity of Cu(II) and Fe(III) complexes of a new tridentate Schiff base ligand. J. Chem. Pharm. Res.4: 4275-4282.
Uddin MM, Salam MA, Sultana J (2015) Pb(II) complexes of Schiff bases derived from benzoylhydrazine as the antibacterial agents”, J. Science publishing group 3:7-14.
El-Ajaily M-M, Abdlseed F-A, Gweirif B, “Preparation, characterization and antibacterial activity of some metal ion complexes”, E-Journal of Chem., vol. 4, pp. 461-466, 2007).
Sharif SAI, El-Tajoury AN, Elamar AA (2011) Preparation and Antibacterial Activity of Mixed Ligand Complexes of Co(II), Ni(II), Cu(II) and Cd(II) Derived from 1-Phenylazo-2-naphthol and Salicylaldehyde. E-Journal of Chemistry 8: 43-48.
Ran X, Wang L, Cao D, Lin Y, Hao J (2011) Synthesis, characterization and in vitro biological activity of cobalt(II), copper(II) and zinc(II) Schiff base complexes derived from salicylaldehyde and D, L-selenomethionine. Appl. Organometal. Chem. 25: 9–15.
Zahan MKE, Islam MS, Bashar MA (2015) Synthesis, Characterization and antimicrobial activity of Some Metal Complexes of Mn(II), Fe(III) Co(II), Ni(II), Cu(II) and Sb(III) Containing Bidentate Schiff base of SMDTC. Russian Journal of general chemistry 85: 667-672.
Geary WJ (1971) The use of conductivity measurements in organic solvents for the characterization of coordination compounds. Coord. Chem. Rev. 7: 81-122.
Shamsuddin Ahamed AK, Benui -D, Siddique A, Datta M (1999) J. Bang. Chem. Soc. 12: 25.
Sadler PJ, Nast M, Narayaran MM (1989) The design of metal complex as anticancer drugs. Murtius-Nijhoff, Boston.
Hutchinson B, Takemoto J, Nakamoto K (1970) Metal isotope effect on metal-ligand vibration. II. Tris complexes of 2, 2/-bipyridine and 1, 10-phenanthroline. J. Am. Chem. Soc. 92: 3335.
Saito Y, Takemoto J, Hutchinson B, Nakamoto K (1972) Infrared studies of coordination compounds containing low-oxidation state metals. I. Tris (2,-2/-bipyridine) and tris (1, 10-phenanthroline) complexes. Inorg. Chem. 11: 2003.
Figgis B-N, Lewis J (1964) The magnetic properties of transition metal complexes. Prog. Inorg. Chem. 6: 73.
Lever ABP (1984) Inorganic Electronic Spectroscopy, 2nd Edn. Elsevier.
Shampa JA, Islam, MR, Hossain MS, Rahman GT, Zakaria CM, Zahan, MK (2017) Physiochemical and Antibacterial Activity Investigation on Noble Schiff Base Cu(II) Complex. American Journal of Heterocyclic Chemistry 3(4): 37-41.
Patel, KM, Patel KN, Patel NH, Patel MN (2001) Synthesis, characterization, and antimicrobial activities of some transition metal complexes with a tridentate dibasic Schiff base and bidentate 2, 2’-bipyridylamine. Synth. React. Inorg. Met-Org. Chem. 31: 239-246.
Temel H, Cakir Ü, Ugras HI, Sekerci M (2003) The Synthesis, Characterization and Conductance Studies of New Co(III), Cu(II), Ni(II) and Zn(II) Complexes with Schiff Base Derived from 1,2-bis-(o-aminophenoxy) Ethane and Salicylaldehyde. J. Coord. Chem. 56: 943-951.
Liang Y, SU B, Zhao I, Sun W (2004) The Synthesis of New Asymmetric Double Schiff Bases Containing a New o‐Amino Benzoic Acid Derivative. Synthesis Communications 34: 3235-3242.
Venkataraman NS, Kuppuraj G, Rajajopal S (2005) Metal-salen complexes as efficient catalysts for the oxygenation of heteroatom containing organic compounds-synthetic and mechanistic aspects. Coord. Chem. Rev. 249: 1249-1268.
Mohamed GG, Omar MM, Hindy AM (2006) Metal complexes of Schiff bases: preparation, characterization and biological activity. J. Turk. Chem. 30: 361-382.
Diego M, Veronica D, Claudia P, Jean PT, Sandra S (2010) Synthesis, characterization and antioxidant activity of water soluble Mn (III) complexes of sulphonato-substituted Schiff base ligands. J. Inorg. Biochem. 104: 496-502.
Khalil M, Ismail E, Mohamed G, Zayed E, Badr A. (2012) Synthesis and characterization of a novel schiff base metal complexes and their application in determination of iron in different types of natural water. Open J. Inorg. Chem. 2: 13-21.
Abu-El-Wafa, SM, El-Wakiel NA, Issa RM, Mansour RA (2005) Formation of novel mono-and multi-nuclear complexes of Mn(II), Co(II) and Cu(II) with bisazo-dianils containing the pyrimidine moiety: Thermal, magnetic and spectral studies. J. Coord. Chem. 58: 683-694.
Etaiw SH, Abd El-Aziz DM, Abd El-Zaher EH, Ali EA (2011) Synthesis, spectral, antimicrobial and antitumor assessment of Schiff base derived from 2-aminobenzothiazole and its transition metal complexes. Spectrochim. Acta A 79: 1331–1337.
Ueda JI, Takai N, Shiazue Y (1998) Reactive Oxygen Species Generated from the Reaction of Copper (II) Complexes with Biological Reductants Cause DNA Strand Scission. Arch. Biochem. Biophys 357: 231-239.
Radhakrishnan PK (1986) Complexes of lanthanide perchlorates with 4-N-(2′-hydroxy-1′-naphthylidene) aminoantipyrine. Polyhedron 5: 995-998.
Maurya RC, Mishra DD, Pandey M, Shukla P, Rathour R (1993) Synthesis and spectral studies of octacoordinated dioxouranium (VI) complexes with some Schiff bases derived from 4-Acetyl-2,3-Dimethyl-l-(4-Methylphenyl)-3-Pyrazoline-5-One and aromatic amines. Synth. React. Inorg. Met. Org. Chem. 23: 161-174.
El-ajaily MM, Maihub AA, Hudere SS, Ben Saber SM (2006) Nickel II Chelate of Schiff base derived from 4-dimethyl-amino-benzaaldehyde with Systeine. Asian Journal of Chemistry Society 18: 2427- 2430.
Morad, FM, EL. ajaily MM, Gweirif SB (2007) Preparation, Physical Characterization and Antibacterial Activity of Ni (II) Schiff Base Complex. J. Sci. and Its Appl.1: 72-78.
Hossain MM, Bashar MA, Khan MN, Roy PK, Ali MS, Farooque MA (2018) Preparation, Physical Characterization and Antibacterial Activity of Ni (II), Cu (II), Co (II), Cd (II), Zn (II) and Cr (III) Schiff Base Complex Compounds. Sci. J. Chem. 6: 17-23.
Agwara MO, Ndifon PT, Ndosiri NB, Paboudam AG, Yufanyi DM, Mohamadou A (2010) Synthesis, Characterization and Anitimicrobial activities of Cobalt (II), Copper (II) AND Zinc (II) Mixed-ligand Complexes contacting 1,10-Phenanthroline and 2,2-Bipyridine. Bull. Chem. Soc. Ethiop. 24(3):383-389.
Tumer M, Celik C, Koksal H, Serin S (1999) Transition metal complexes of bidentate Schiff base ligands. Transition Metal Chemistry 24: 525-532.
Singh D, Singh VS (2016) Phytochemical Analysis and Antimicrobial Activity of Chloroform Extract of Abutilon indicum. American Journal of Applied Chemistry 4(6): 242-246.
Fatondji HR, Kpoviessi S, Gbaguidi F, Sika KC, Gbenou J, Accrombessi GC, Moudachirou M, Poupaert J (2018) Synthesis, Characterization and Antimicrobial Properties of Some 1,3,4-Thiadiazolines. American Journal of Applied Chemistry 6(2): 64-70.
Patel RN, Singh N, Shukla KK, Chauhan UK, Gutierrez JN, Castineiras A (2004) Magnetic, Spectroscopic, Structural and Biological Properties of Mixed-ligand Complexes of Copper(II) with N,N,N¢,N²,N²-Pentamethyldiethylenetriamine and Polypyridine ligands Inorganica Chimica Acta 357: 2469–2476.
Mohamed GG*, Omar MM, Ibrahim AA (2009) Biological activity studies on metal complexes of novel tridentate Schiff base ligand. Spectroscopic and thermal characterization. European Journal of Medicinal Chemistry 44: 4801–4812.
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