Volume 7, Issue 2, April 2019, Page: 64-71
Synthesis, Characterisation and Acetylcholinesterase Inhibition Activity of Nickel(II) and Copper(II) Complexes of 3-Hydroxybenzaldehyde-4-nitrobenzoic Acid Hydrazone
Temitope Adekunle Ajayeoba, Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Olawale Folorunso Akinyele, Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Ayowole Olaolu Ayeni, Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Idowu Julius Olawuni, Department of Biochemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Received: Feb. 28, 2019;       Accepted: Apr. 29, 2019;       Published: May 26, 2019
DOI: 10.11648/j.ajac.20190702.14      View  244      Downloads  51
Abstract
A new ligand namely 3-hydroxybenzaldehyde-4-nitrobenzoic acid hydrazone, its Nickel(II) and Copper(II) complexes were synthesised and characterised by spectroscopic methods: 1H NMR, Infrared (IR), UV-Vis, magnetic susceptibility measurement and % metal analysis. 1H NMR spectroscopy showed the diagnostic N-H signal at 12.10 ppm indicating the formation of the ligand. Infrared spectra showed that the ligand coordinated to the metal ion in keto form through the carbonyl oxygen (C=O) and the azomethine nitrogen (C=N). The UV-Vis spectrum of the ligand displayed two prominent bands at 47169 cm-1 and 30303 cm-1 which were ascribed to the intraligand transitions of π-π*, and n-π* respectively. These bands had hypsochromic shifts in the metal complexes indicating coordination with the metal ion. The nickel complex had a magnetic moment of 2.92 B.M, suggesting an octahedral geometry, while the copper complex had a value of 1.65 B.M. which is close to the expected value for a d9 copper(II) complex with possibility antiferromagnetic interactions. The % metal calculated had a good agreement with the observed values. The acetylcholinesterase inhibition activity of the ligand measured was 190 ± 20 μg/mL compared to the standard Eserin that had 68 ± 1.13 μg/mL. The copper(II) complex had a value of 220 ± 20 μg/mL, while the Nickel(II) complex had the least inhibitory value at 390 ± 80 μg/mL. The compounds could serve as primary target in the study of acetylcholinesterase inhibitors
Keywords
3-Hydroxybenzaldehyde-4-nitrobenzoic Acid Hydrazone, Acetylcholinesterase Inhibition, Octahedral Geometry
To cite this article
Temitope Adekunle Ajayeoba, Olawale Folorunso Akinyele, Ayowole Olaolu Ayeni, Idowu Julius Olawuni, Synthesis, Characterisation and Acetylcholinesterase Inhibition Activity of Nickel(II) and Copper(II) Complexes of 3-Hydroxybenzaldehyde-4-nitrobenzoic Acid Hydrazone, American Journal of Applied Chemistry. Vol. 7, No. 2, 2019, pp. 64-71. doi: 10.11648/j.ajac.20190702.14
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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