Volume 8, Issue 1, February 2020, Page: 13-22
Phytochemical Composition, Biological Activities of Croton lobatus L. Leaves, Hydrolysis Effect on Activities and Chemical Composition
Marthe Dominique Chodaton-Zinsou, Faculty of Sciences and Technics, University of Abomey-Calavi, Abomey-Calavi, Benin
Fidèle Mahoudo Assogba, Faculty of Sciences and Technics, University of Abomey-Calavi, Abomey-Calavi, Benin
Eléonore Yayi-Ladékan, Faculty of Sciences and Technics, University of Abomey-Calavi, Abomey-Calavi, Benin
Fernand Gbaguidi, Faculty of Sciences and Technics, University of Abomey-Calavi, Abomey-Calavi, Benin
Mansourou Moudachirou, Faculty of Sciences and Technics, University of Abomey-Calavi, Abomey-Calavi, Benin
Joachim Djimon Gbénou, Faculty of Sciences and Technics, University of Abomey-Calavi, Abomey-Calavi, Benin
Received: Feb. 5, 2020;       Accepted: Feb. 27, 2020;       Published: Mar. 10, 2020
DOI: 10.11648/j.ajac.20200801.13      View  48      Downloads  35
Abstract
Croton lobatus L. is medicinal plant widely used in traditional medicine, but little known in literature for its biological properties. Aims were to study its phytochemical composition and some biological properties and influence of acid hydrolysis on biological activities and chemical composition of Croton lobatus L. extracts. Successive extractions with solvents of increasing polarity (cyclohexane, ethyl acetate, and methanol) were carried out on powder of Croton lobatus L. leaves. Evaluation of xanthine oxidase, acetylcholinesterase, 5-lipoxygenase and α-amylase inhibitions, antioxidant activity was performed. Acid hydrolysis effect was evaluated by comparison of chemical composition and xanthine oxidase, α-amylase inhibition activities of hydrolyzed and unhydrolyzed extracts. Results showed that at 50 mg/L Croton lobatus L. has very small antioxidant activity (3.4 - 4.9%), small inhibitory activity of 5-lipoxygenase (6.3-6.9%), inhibitory activity of acetylcholinesterase between (2.7 - 31.3%), moderate inhibitory activity of α-amylase (52.8 - 64.3%), moderate inhibitory activity of xanthine oxidase (22.2 - 62.6%). Croton lobatus L. could be used in diabetes and gout treatments, given results of α-amylase inhibition and xanthine oxidase. Acid hydrolysis has negative effect on process of xanthine oxidase inhibition and on chemical composition.
Keywords
Croton lobatus L., Antioxidant, Acetylcholinesterase, Xanthine Oxidase, α-amylase, 5-Lipoxygenase, Inhibition, Acid Hydrolysis
To cite this article
Marthe Dominique Chodaton-Zinsou, Fidèle Mahoudo Assogba, Eléonore Yayi-Ladékan, Fernand Gbaguidi, Mansourou Moudachirou, Joachim Djimon Gbénou, Phytochemical Composition, Biological Activities of Croton lobatus L. Leaves, Hydrolysis Effect on Activities and Chemical Composition, American Journal of Applied Chemistry. Vol. 8, No. 1, 2020, pp. 13-22. doi: 10.11648/j.ajac.20200801.13
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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